Dissemination & Communication

GENERAL PRESS ARTICLE

Training the new generation of scientists for side effect-free chemotherapies. Published on CORDIS Magazine, October 2020. https://cordis.europa.eu/article/id/422368-training-the-new-generation-of-scientists-for-side-effect-free-chemotherapies/es

SCIENTIFIC PUBLICATIONS

Architectural Change of the Shell-Forming Block from Linear to V‑Shaped Accelerates Micellar Disassembly, but Slows the Complete Enzymatic Degradation of the Amphiphiles. Merav Segal, Lihi Ozery, Gadi Slor, Shreyas Shankar Wagle (ESR2, TAU), Tamara Ehm, Roy Beck, and Roey J. Amir (TAU). Biomacromolecules 2020, 21, 4076−4086. https://pubs.acs.org/doi/10.1021/acs.biomac.0c00882?ref=pdf

Transition metal catalysts for the bioorthogonal synthesis of bioactive agents. Melissa O.N. van de L’Isle (ESR11, EDI), Mari Carmen Ortega-Liebana, Asier Unciti-Broceta (EDI). Current Opinion in Chemical Biology, 61, 2021, 32-42. https://www.sciencedirect.com/science/article/pii/S1367593120301307

Targeting Glioblastoma: Advances in Drug Delivery and Novel Therapeutic Approaches. Eilam Yeini, Paula Ofek, Nitzan Albeck, Daniel Rodriguez Ajamil (ESR13, TAU), Lena Neufeld, Anat Eldar‐Boock, Ron Kleiner, Daniella Vaskovich, Shani Koshrovski‐Michael, Sahar Israeli Dangoor, Adva Krivitsky, Christian Burgos Luna, Gal Shenbach‐Koltin, Miki Goldenfeld, Ori Hadad, Galia Tiram, Ronit Satchi‐Fainaro (TAU). Adv. Therap. 2021, 4, 2000124. https://doi.org/10.1002/adtp.202000124

Tuning the Reactivity of Micellar Nanoreactors by Precise Adjustments of the Amphiphile and Substrate Hydrophobicity. Shahar Tevet, Shreyas S. Wagle (ESR2, TAU), Gadi Slor, and Roey J. Amir (TAU). Macromolecules2021, 54 (24), 11419–11426. https://pubs.acs.org/doi/full/10.1021/acs.macromol.1c01755

Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks. Gadi Slor, Alis R. Olea (ESR7, IBEC), Sílvia Pujals, Ali Tigrine, Victor R. De La Rosa, Richard Hoogenboom, Lorenzo Albertazzi (IBEC, TUE), Roey J. Amir (TAU). Biomacromolecules 2021, 22, 1197-1210. https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.0c01708

Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells. Linlin Deng (ESR8, TUE), Lorenzo Albertazzi (IBEC, TUE), and Anja R. A. Palmans (TUE). Biomacromolecules 2022, 23 (1), 326–338. https://pubs.acs.org/doi/10.1021/acs.biomac.1c01291

En Route to Stabilized Compact Conformations of Single-Chain Polymeric Nanoparticles in Complex Media. Stefan Wijker, Linlin Deng (ESR8, TUE), Fabian Eisenreich, Ilja K. Voets, and Anja R. A. Palmans (TUE). Macromolecules 2022, 55 (14), 6220–6230. https://pubs.acs.org/doi/10.1021/acs.macromol.2c00930

Design and Evolution of Chimeric Streptavidin for Protein-Enabled Dual Gold Catalysis. Christoffel, F., Igareta, N., Pellizzoni, M. M., Tiessler-Sala, L., Lozhkin, B. (ESR10, BAS), Spiess, D. C., Lledos, A., Marechal, J.-D., Peterson, R. L., Ward, T. R. (BAS). Macromolecules 2022 55 (14), 6220-6230. https://www.nature.com/articles/s41929-021-00651-9

Bioorthogonal Strategies for the in Vivo Synthesis or Release of Drugs. Lozhkin, B. (ESR10, BAS); Ward, T. R. (BAS). Med. Chem. 45 (2021) 11631. https://www.sciencedirect.com/science/article/pii/S0968089621003187?via%3Dihub

A Close-to-Aromatize Approach for the Late-Stage Functionalization through Ring Closing Metathesis. Lozhkin, Boris (ESR10, BAS); Ward, Thomas R. (BAS). Chim. Acta, May 2021, vol 104, issue 5. https://onlinelibrary.wiley.com/doi/10.1002/hlca.202100024

Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development? Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil (ESR13, TAU), Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman, Ronit Satchi-Fainaro (TAU). Advanced Drug Delivery Reviews, Volume 175, 2021, 113760. https://www.sciencedirect.com/science/article/abs/pii/S0169409X21000983?via%3Dihub

CONFERENCES, CONGRESSES AND SEMINARS

Michela Vargiu (ESR1)
The Netherlands’ Catalysis and Chemistry Conference (NCCC) 2020, Noordwijkerhout, The Netherlands. Novel metal complexes and strategies for bio-orthogonal catalytic uncaging of prodrug. M. Vargiu and G.Roelfes. Poster, 02/03/2020 to 04/03/2020. https://www.vo.eu/event/nccc-conference-2020/

CHAINS – Chemistry as innovative science 2020, online. Functional Group Interconversion-to-Release: a new approach to bioorthogonal uncaging of prodrugs. M. Vargiu and G.Roelfes. Poster, 08/12/2020 and 09/12/2020. https://nwochains.nl/watch-chains2020/

Shreyas Wagle (ESR2)
The Israeli Chapter of the Controlled Release Society (ICRS) and the Polymers for Advanced Technologies Society (PAT). Elucidating the Effect of Hydrophobicity on the Kinetics of Bioorthogonal Pd-mediated reaction within micellar nanoreactors. Shreyas Wagle, Shahar Tevet, Gadi Slor, Roey Amir. Poster, 03/10/2021. https://icrs-pat2021.org.il/

13th Annual Meeting of Fred Chaoul Nano Center Community. Elucidating the Effect of Hydrophobicity on the Kinetics of Bioorthogonal Pd-mediated reaction within micellar nanoreactors. Shreyas Wagle, Shahar Tevet, Gadi Slor, Roey Amir. Poster, 13/02/2022. https://nano.tau.ac.il/sites/nano.tau.ac.il/files/media_server/Nano/FredShaul_Prog_Update.pdf

End of the year poster session in Tel-Aviv University. Studying the influence of polymeric architecture on the depropargylation kinetics inside palladium loaded micellar nanoreactors. Shreyas Wagle, Parul Rathee, Roey Amir. Poster, 09/06/2022. https://en-exact-sciences.tau.ac.il/chemistry/

European Polymer Congress EPF 2022. Studying the influence of polymeric architecture on the depropargylation kinetics inside palladium loaded micellar nanoreactors. Shreyas Wagle, Parul Rathee, Roey Amir. Poster, 01/07/2022. https://www.epf2022.org/

THERACAT – Final Meeting. Studying the influence of polymeric architecture on the depropargylation kinetics inside palladium loaded micellar nanoreactors. Shreyas Wagle, Parul Rathee, Roey Amir. Poster, 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Krishna Vippala (ESR3)
13th Annual Meeting of Fred Chaoul Nano Center Community. Studying the effect of polymer architecture on reaction rate in organometallic micellar nanoreactors. Krishna Vippala, Shreyas Wagle, Bianca Avramovitch, Roey Amir. Poster, 13/02/2022. https://nano.tau.ac.il/sites/nano.tau.ac.il/files/media_server/Nano/FredShaul_Prog_Update.pdf

End of the year poster session in Tel-Aviv University. Studying the effect of polymer architecture on reaction rate in organometallic micellar nanoreactors. Krishna Vippala, Shreyas Wagle, Bianca Avramovitch, Roey Amir. Poster, 09/06/2022. https://en-exact-sciences.tau.ac.il/chemistry/

THERACAT – Final Meeting. Studying the effect of polymer architecture on reaction rate in organometallic micellar nanoreactors. Krishna Vippala, Shreyas Wagle, Bianca Avramovitch, Roey Amir. Poster, 07/07/22. https://theracat.eu/theracat-meeting-and-conference/

Anjana Sathyan (ESR4)
Colloquium at the TU Eindhoven (Eindhoven, THE NETHERLANDS). Single chain polymeric nanoparticles as catalyst carriers for prodrug activation. Anjana Sathyan. 14/12/2019.

CHAINS – Chemistry as innovative science 2020, online. Single chain polymeric nanoparticles for pro-drug activation. Anjana Sathyan, Anja Palmans. Poster, 08/12/2020 and 09/12/2020. https://nwochains.nl/watch-chains2020/

Brightland polymer days. Improving the efficiency of Pd (II) based amphiphilic polymeric nanoparticles for bio-orthogonal catalysis in complex media. Anjana Sathyan, Ana M. Pérez-López , Catherine Adam , Bas de Waal , Asier Unciti-Broceta and Anja R.A Palmans. Poster, 7/9-11-2021. https://polymerdays.brightlands.com/

CHAINS 2021. Improving the efficiency of Pd (II) based amphiphilic polymeric nanoparticles for bio-orthogonal catalysis in complex media. Anjana Sathyan, Ana M. Pérez-López , Catherine Adam , Bas de Waal , Asier Unciti-Broceta and Anja R.A Palmans. Poster, 7/8- 12-2021. https://nwochains.nl/

CHAINS 2021. Amphiphilic polymeric nano-particles as bio-orthogonal catalysts for pro-drug activation. Anjana Sathyan, Ana M. Pérez-López , Catherine Adam , Bas de Waal , Asier Unciti-Broceta and Anja R.A Palmans. Oral, 7/8- 12-2021. https://nwochains.nl/

ICMS symposium. Cu-SCPNs as versatile catalysts in water. Anjana Sathyan, Anja R.A Palmans. Poster, 24/03/2022. https://www.tue.nl/en/our-university/calendar-and-events/24-03-2022-icms-annual-symposium-2022/

FMS ANNUAL MEETING. Cu-SCPNs as versatile catalysts in water. Anjana Sathyan, Anja R.A Palmans. Poster, 13/05/2022. https://fmsresearch.nl/fms-annual-meeting/

THERACAT – Final Meeting. Developing Single-chain polymeric nanoparticles for bio-orthogonal catalysis. Anjana Sathyana, Anja Palmans. Poster and oral presentation. 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Stephen Croke (ESR5)
Seminar at Institute of Genetics & Molecular Medicine (Edinburgh, UK). Targeting Cancer Through the Local Destruction of Proteins. Oral presentation, 21/01/2020.

THERACAT – Final Meeting. Exploring bioorthogonal approaches to activate PROTACS. Stephen Croke, Melissa van de L’Ilse, Mari Carmen Ortega-Liebana and Asier Unciti-Broceta. Poster and oral presentation. 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Manos Archontakis (ESR6)
THERACAT – Final Meeting. Super-Resolution Microscopy on Catalytic Single-Chain Polymeric Nanoarticles: towards single-particle structure and function. Emmanouil Archontakis. Oral presentation, 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

THERACAT – Final Meeting. A Spectrally-resolved view at nanoparticle functionality. Emmanouil Archontakis. Poster and oral presentation. 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Alis R. Olea (ESR7)
13th IBEC Symposium, online. Judging micelles by their covers: combining molecular precision and self-reporting mechanism for a direct comparison of dendritic amphiphiles with different hydrophilic blocks. Alis R. Olea, Gadi Slor, Sílvia Pujals, Victor R. De La Rosa, Richard Hoogenboom, Lorenzo Albertazzi and Roey J. Amir. Poster, 27/10/2020 and 28/12/2020. https://ibecbarcelona.eu/es/event/13th-ibec-symposium-bioengineering-for-future-and-precision-medicine/

THERACAT – Final Meeting. Tuning tumor penetration: dynamics of polymeric micelles inside an in vitro tumor-on-a-chip model with dual ECM. Alis R. Olea, Alicia Jurado, Gadi Slor, Shahar Tevet, Sílvia Pujals, Roey J. Amir and Lorenzo Albertazzi.Poster. 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Linlin Deng (ESR8)
Colloquium at the TU Eindhoven (Eindhoven, THE NETHERLANDS). A study on the stability of single chain polymeric nanoparticles in complex media. Oral presentation, 17/02/2020.

CHAINS – Chemistry as innovative science 2020, online. Stability of SCPNs as a function of medium complexity. Linlin Deng, Anja Palmans. Poster, 08/12/2020 and 09/12/2020. https://nwochains.nl/watch-chains2020/

CHAINS 2021. Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells. Linlin Deng, Lorenzo Albertazzi, and Anja R. A. Palmans. Poster, 7/8- 12-2021. https://nwochains.nl/

Brightland polymer days. Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells. Linlin Deng, Lorenzo Albertazzi, and Anja R. A. Palmans. Poster, 7/9-11-2021. https://polymerdays.brightlands.com/

ICMS symposium. Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells. Linlin Deng, Lorenzo Albertazzi, and Anja R. A. Palmans. Poster, 24/03/2022. https://www.tue.nl/en/our-university/calendar-and-events/24-03-2022-icms-annual-symposium-2022/

THERACAT – Final Meeting. Elucidating the Stability and functionality of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells. Linlin Deng, Lorenzo Albertazzi, and Anja R. A. Palmans. Poster and oral presentation, 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Africa Galvez-Flores (ESR9)
Biomaterials Seminar Series at the Centre for the Cellular Microenvironment (University of Glasgow, UK). An In-vitro 3D Model for Chemotherapy Testing. Oral presentation, 26/11/2019.

Goodbye Flat Biology, Berlin, Germany. 3D Hydrogels and Bioinks for Realistic In-vitro Cancer Modelling. Poster, 11/11/2019.

Joint 3DBioNet IBIN Meeting, London, UK. 3D Hydrogels and Bioinks for In-vitro modelling in Advanced Therapies. Poster, 20/01/2020

THERACAT – Final Meeting. Suitability of 3D Fmoc-FF/S Hydrogels for anticancer drug discovery. Africa Galvez-Flores, Ewelina Morawska, Chris Allan, Laura Goldie, Matthew Dalby, Rein Ulijn. Poster, 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Boris Lozhkin (ESR10)
22nd Tetrahedron Symposium. Catalysis for a Sustainable World. Artificial deallylase directed prodrug activation on tumor cells. Boris Lozhkin, Brett Garabedian, Alina Stein, Robin Vinck, Johannes Rebelein, Thomas Ward. Poster, 28.06.2022 – 01.07.2022. https://www.elsevier.com/events/conferences/tetrahedron-symposium

Maria Vlastara (ESR12)
Presentation at the Nuclear Medicine Department, Radboud University Medical Center (Nijmegen, The Netherlands). In-vivo click and click-to-release strategies for in vivo catalyst activation. Oral presentation, 28/05/2019.

THERACAT – Final Meeting. “Click-to-release” to Boost Tumor-Blood Ratios with trans-cyclooctene-DFO Functionalized Trastuzumab in Mice. Maria Vlastara, Raffaella Rossin, Freek JM Hoeben, Ron M. Versteegen, Henk ten Hoeve, Wolter ten Hoeve, Marc S. Robillard. Poster. 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

Daniel Rodriguez (ESR13)
ICRS-PAT 2021 (CRS Israel local chapter). Design of targeted PLGA-SO3 Nanoparticles encapsulating PARP and PD-L1i for BRCA-Mutated breast cancer therapy. Daniel Rodriguez Ajamil, Shani Koshrovski-Michael, Pradip Dey. Poster, 3.10.21-7.10.21. https://icrs-pat2021.org.il/

The 13th Annual Meeting of Fred Chaoul Nano Centre Community. Design of targeted PLGA-SO3 Nanoparticles encapsulating PARP and PD-L1i for BRCA-Mutated breast cancer therapy. Daniel Rodriguez Ajamil, Shani Koshrovski-Michael, Pradip Dey. Poster and oral presentation, 13.02.22-15.02.22. https://nano.tau.ac.il/events/13th-annual-meeting-of-the-fred-schaul-nano-center-community-11-1-2022

CBRC Virtual Seminars. Design of targeted PLGA-SO3 Nanoparticles encapsulating PARP and PD-L1i for BRCA-Mutated breast cancer therapy. Daniel Rodriguez Ajamil, Shani Koshrovski-Michael, Pradip Dey. Oral presentaion, 16.05.22. https://cbrc.tau.ac.il/events/cbrc-18th-virtual-seminar-dna-and-cancer-much-more-than-just-mutations-25-4-2022?instance=1650891600&gid=19

Israeli Society for Cancer Research (ISCR). Design of targeted PLGA-SO3 Nanoparticles encapsulating PARP and PD-L1i for BRCA-Mutated breast cancer therapy. Daniel Rodriguez Ajamil, Shani Koshrovski-Michael, Pradip Dey. Poster, 31.05.22. https://www.iscr.org.il/%D7%9B%D7%A0%D7%A1%D7%99%D7%9D/%D7%9B%D7%A0%D7%A1-%D7%94%D7%90%D7%A8%D7%92%D7%95%D7%9F-2022/

THERACAT conference. Design of targeted PLGA-SO3 Nanoparticles encapsulating PARP and PD-L1i for BRCA-Mutated breast cancer therapy. Daniel Rodriguez Ajamil, Shani Koshrovski-Michael, Pradip Dey. Poster ? Oral presentation, 01/07/2022. https://theracat.eu/theracat-meeting-and-conference/

CRS (Controlled Release Society) Annual meeting. Design of targeted PLGA-SO3 Nanoparticles encapsulating PARP and PD-L1i for BRCA-Mutated breast cancer therapy. Daniel Rodriguez Ajamil, Shani Koshrovski-Michael, Pradip Dey. Poster, 11.07.22 – 15.07.22. https://www.eventscribe.net/2022/CRSAnnualMeeting/

OUTREACH ACTIVITIES

  • Stephen Croke (ESR5), Melissa van de L’Isle (ESR11) and Asier Unciti-Broceta (EDI). Short stay of High School student (Eva Russo) from Algeciras (Spain) that won a Diverciencia scholarship to visit EDI lab and learn on bioorthogonal chemistry (Edinburgh, UK). 02-06/09/2019. https://www.europasur.es/algeciras/omar-rodriguez-eva-russo-diverciencia_0_1360364158.html
  • Manos Archontakis (ESR6): Demonstration of microscope facilities for BSc students at TUE (Eindhoven, THE NETHERLANDS). 11/2019
  • Alis Olea (ESR7): Participation in «(Re)search4Talent» event for undergraduate and master students interested in a research career at IBEC (Barcelona, SPAIN). 21/05/2019
  • Africa Galvez (ESR9): Company Monthly Update: An Overview of the THERACAT Project. In this online talk of about 30 min she explained the THERACAT project to her Biogelx colleagues, with a presentation targeted to a general audience. 09/06/2020.
  • Boris Lozhkin (ESR10) and Thomas Ward (BAS). Chemistry Olympiad Workshop for gifted Swiss high school students (Basel, SWITZERLAND). 23/11/2019
  • Boris Lozhkin (ESR10): Practical courses in general chemistry for students of the Faculty of Chemistry, University of Basel, Switzerland. From 04.10.2020 to 23.12.2020
  • Boris Lozhkin (ESR10): Practical courses in general chemistry, during the period 01.03.2021 – 04.06.2021, for 9 students of the Faculty of Chemistry from the University of Basel, Switzerland.
  • Maria Vlastara (ESR12): Hands-on-sessions at the Radboud University Medical Center Summer school “State of the art Radionuclide Imaging and Therapy in Oncology” (Nijmegen, THE NETHERLANDS). 12-16/08/2019
  • Daniel Rodriguez (ESR13): Participation in the scientific outreach event from the CRS, the Controlled Release Society at Montreal, Canada (https://www.controlledreleasesociety.org/) to a young committee.

OTHER ACTIVITIES

NEWS ON BENEFICIARIES’ WEBSITES

SOCIAL NETWORKS

THERACAT Twitter account (https://twitter.com/theracatEU): from November/2020 to January/2021 Krishna Vippala (ESR3), Shreyas Shankar Wagle (ESR2), Emmanouil Archontakis (ESR6), Alis Olea Rodica (ESR7), Africa Galvez-Flores (ESR9), Melissa Van de l’Isle (ESR11) and Daniel Rodríguez Ajamil (ESR13) were in charge to manage the account publications. More than 80 tweets were published and the account has gained more than 55K impressions.